MOTS-C Clinics in the United States

What Is MOTS-C?

MOTS-C is a mitochondrial-derived peptide encoded in the mitochondrial genome that acts as a metabolic regulator. It is one of a new class of 'mitokines' - signaling molecules produced by mitochondria that coordinate metabolic responses throughout the body.

MOTS-C improves insulin sensitivity, promotes glucose uptake in muscles, enhances exercise capacity, and has demonstrated life-extending effects in animal models. It mimics the metabolic benefits of exercise at the cellular level and has strong anti-inflammatory properties. Research suggests it may help prevent age-related metabolic decline, obesity, and type 2 diabetes.

It is administered via subcutaneous injection.

Who Considers MOTS-C?

• Adults with metabolic syndrome, insulin resistance, or pre-diabetes
• People interested in mitochondrial health and longevity medicine
• Athletes and active individuals seeking improved endurance and metabolic efficiency
• Those pursuing anti-aging protocols focused on cellular health

What to Expect at a Consultation

MOTS-C is typically prescribed as part of a comprehensive longevity or metabolic health protocol. Consultation will include metabolic markers, insulin sensitivity testing, and health history.